Effect of drug transporter genotypes on pravastatin disposition in European-and African-American participants
RH Ho, L Choi, W Lee, G Mayo… - Pharmacogenetics …, 2007 - journals.lww.com
Objective Our aims were to evaluate the effects of polymorphisms in the hepatic drug uptake
transporter organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) and efflux
transporters multidrug resistance-associated protein 2 (MRP2, ABCC2), bile salt export
pump (BSEP, ABCB11), and breast cancer-related protein (BCRP, ABCG2) on single-dose
pravastatin pharmacokinetics in healthy European-and African-American participants.
Methods The pharmacokinetics of a single oral 40 mg dose of pravastatin was determined in …
transporter organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) and efflux
transporters multidrug resistance-associated protein 2 (MRP2, ABCC2), bile salt export
pump (BSEP, ABCB11), and breast cancer-related protein (BCRP, ABCG2) on single-dose
pravastatin pharmacokinetics in healthy European-and African-American participants.
Methods The pharmacokinetics of a single oral 40 mg dose of pravastatin was determined in …
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